Aptamer dimer
Web29 gen 2008 · Each aptamer recognizes a different part of the thrombin molecule, and the aptamer dimer has a Kd value which is 1/10 of that of the monomers from which it is composed. Also, the designed aptamer dimer has higher inhibitory activity than the reported (15-mer) thrombin-inhibiting aptamer. WebAfter 11 rounds, four aptamers with anti-hTNF-α inhibitory effect were identified. The truncation and dimerization strategy revealed a new dimer aptamer with 67 nM Kd, …
Aptamer dimer
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Web10 mag 2024 · Furthermore, the positively charged cavity formed at the dimer-of-dimers interface in the crystal structure of the HIV-1 IN (PDB code 1K6Y) has also been suggested as a suitable site for DNA and ... Web26 mar 2024 · The aptamer-based targeted therapeutics can be divided into the following three approaches according to aptamers’ function mechanisms: (1) The aptamer directly acts as the therapeutic agent to block the function of target through interaction with it and participates in the treatment of related disease; (2) The aptamer acts as an agonist, …
WebResearchGate Web14 apr 2024 · This study developed an aptamer‐based ELISA (enzyme‐linked immunosorbent assay) system for sensitive detection of D‐dimer molecule which is …
Web28 nov 2024 · Using a dimer to recognize a protein target represents the simplest multivalency system. Web22 ott 2024 · A simple method based on a thiamonomethinecyanine dye (dye2) and duplex DNA system was constructed to detect Pb2+ by UV–Vis spectra. The absorption spectra of dye2 show dimers and monomers peak and the monomer–dimer equilibrium could be regulated with environmental change. Duplex DNA as a template was used to regulate …
Web30 ott 2024 · The A43 aptamer, a positive allosteric modulator, ... Each protomer of a dimer is colored green or orange. The A43 aptamer is colored cyan and the insulin is colored magenta.
Web31 mar 2024 · We confirm that these aptamers bind the EpCAM dimer, a complex distinct from and more physiologically relevant than the oft-targeted EpCAM monomer. This successful structure-based in silico approach … geist half marathon 2023Web29 gen 2008 · Each aptamer recognizes a different part of the thrombin molecule, and the aptamer dimer has a Kd value which is 1/10 of that of the monomers from which it is … geist half marathon 2021Web31 mar 2013 · Aptamers are chemically synthesized and selected for their high affinity and specificity for a certain target through the SELEX process [1-3]. Generally speaking, an RNA aptamer is about 56-120 nucleotides long and is comprised of a variable region and a constant region. geist half marathon results 2022Web22 apr 2015 · The L-oligonucleotide is an L-aptamer (a Spiegelmer) identified to bind L-CCL2 with high affinity, ... Similar to other chemokines, CCL2 can form dimers and higher oligomers 3. dd2249 pentagon building pass applicationWeb21 lug 2008 · Figure 3 RNA Aptamer Dimers Are Capable of Enhancing SEB-Induced Proliferation, IFN-γ Production, and Nuclear Translocation of NF-κB Show full caption View Large Image Download Hi-res image Download (PPT) Activation of the OX40 receptor also results in the induction of interferon (IFN)-γ secretion ( Aggarwal, 2003 geist half marathon 2022 routeWeb10 apr 2024 · Several physicochemical characteristics of an identified aptamer, E22P-AbD43, suggested that preferential affinity of this aptamer toward PFs is due to its … geist half marathon promotional codeWeb21 lug 2008 · In this study aptamer dimers were generated by adding short complementary sequences to the 3′-ends of the aptamers and allowing these to anneal in pair-wise … geistheiler wow classic