Dynein light intermediate chain binding
WebOct 1, 2014 · Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by means of its light intermediate chain (LIC). In this study, we have determined the crystal structure of the conserved LIC domain, which binds the motor heavy chain, from a thermophilic fungus. We show that … WebJan 1, 2024 · The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proc. Natl. Acad. Sci. U.S.A., 104 (2007), ... The …
Dynein light intermediate chain binding
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WebMar 30, 2024 · The light-intermediate chain has a Ras-like fold and appears to bind to nucleotides (Schroeder et al., 2014; Toropova et al., 2024). Although nucleotide-binding by the light-intermediate chain does not seem essential for dynein-2 function (Hou et al., 2004), whether it serves a structural role or has a minor regulatory function remains unclear. Webically interacts with an N-terminal region of the dynein inter-mediate chain (15). The intermediate chain (74 kDa) functions as a scaffold that links the different components …
WebThe light intermediate chains associate in the dynein complex only as homoligomers. b ... LC4/Ca+2 binding: Related protein: ... Dynein is part of a complex including dynein … WebAug 8, 2024 · An analysis of dynein-2 subunit interactions via a visible immunoprecipitation (VIP) assay has been published, demonstrating interactions between WDR60 and TCTEX1/3-TCTEX1D2; WDR34 and LC8 and Roadblock; and the intermediate chain-light chain complex with the heavy chain and light-intermediate chain .
WebFeb 5, 2008 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: minus-end-directed microtubule motor activity Source:GO_Central. ... The dynein complex consists of at least two heavy chains and a number of intermediate and light chains. By similarity. Protein-protein interaction databases. BioGRID. 108107 9 ... WebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate chain, light intermediate chain, and three light chains.
WebMar 4, 2024 · Coil: yellow. Ribbons are thickened and non-physical struts added to make more robust for 3D printing. 6f1y-ribbon-rainbow-vis. Molecular ribbon representation with each biopolymer chain colored by rainbow from N-terminus (red) to C-terminus (blue). Intended for visualization only, not 3D printing.
WebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by … thiamphenicol webmdWebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690 … thiamphenicol mechanism of actionWebJan 27, 2006 · Human and mouse cytoplasmic dynein subunit genes. The subunits of the cytoplasmic dynein complexes are resolved into subunit polypeptides of ~530 kDa (heavy chains), ~74 kDa (intermediate chains), ~33–59 kDa (light intermediate chains), and ~10–14 kDa (light chains) in SDS-PAGE gels (Figure 1A).Research on the cytoplasmic … sagemath adjacency matrixWebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major … sage maternity leaveWebMay 15, 2024 · The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which … sagemath 9.3 notebookWebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated and the importance of individual subunits in maintaining cellular homeostasis is unknown. sagemath 9.1 downloadWebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to p53-binding protein 1 and mediates DNA damage-induced p53 nuclear accumulation. J Biol Chem. 2005; 280:8172–8179. [Google Scholar] Lo KW, Naisbitt S, Fan JS, Sheng M, … thiamphenicol structure