WebAug 1, 2024 · PU.1 bound to the CNS3 probe even when the IRF4 binding motif was mutated , probably because the remaining Ets motif in the mutated probe can be bound with monomeric PU.1. To clarify whether PU.1 binds to CNS3 by itself in living cells, we evaluated the effect of IRF4 knockdown on the binding degree of PU.1 to the EICE in CNS3 by a ChIP … WebIRF4 IRF-4 is a member of the interferon regulatory factor (IRF) family of transcription factors, which were first identified as being involved in the expression of interferon-induced genes. From: The Immune Response, 2006 Related terms: CD4 IRF8 T Cells Plasma Cell Lymphoma Germinal Center Cellular Differentiation Phenotype B Cell Proteome
Specificity through cooperation: BATF–IRF interactions
WebApr 24, 2024 · Such diverse functions of IRF4 are thought to rely on multiple DNA binding motifs to which IRF4 binds as heterodimers or its homodimer depending on its protein level. 15 IRF4 binds the Ets-IRF composite elements (EICEs) with PU.1, 16 the AP-1-IRF composite elements (AICEs) with AP-1 family such as Batf, 17, 18, 19, 20 and the interferon sequence … WebSep 2, 2024 · IRF4 and DNA-Binding Motifs IRF4 belongs to the IRF gene family, which encodes basic leucine zipper (bZIP)-type transcription factor proteins. bZIP proteins possess three modular functional regions: dimerization, DNA binding, and transcriptional regulation regions. moto with front camera
Dual Roles of PU.1 in the Expression of PD-L2: Direct …
WebAug 13, 2024 · Interferon regulatory factor 4 (IRF4) is a lymphoid transcription factor and a key regulator in the development of various immune cells, including T and B cells. It is well-known that IRF4 controls numerous decision-making processes relating to B cell … WebAug 25, 2024 · IRF4 is critical to full T cell activation, metabolic upregulation, and function but binds DNA weakly on its own and depends on interactions with other transcription … WebFeb 26, 2024 · Interferon regulatory factor 4 (IRF4) is a key transcription factor (TF) in the regulation of immune cells, including B and T cells. It acts by binding DNA as both a homodimer and, in conjunction with other TFs, as a heterodimer. The choice of homo and heterodimeric/ DNA interactions is a critical a … moto wireless phones