Web14. júl 2024 · Phenylephrine may also cause dose-dependent increases in blood pressure and reductions in heart rate and cardiac output (particularly in people with preexisting … WebPhenylephrine Poor oral bioavailability (38%) due to significant first-pass effect makes toxicity less likely Half-life: 2-3 hours 10 Typical minimum dose required to cause an …

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Web9. aug 2016 · The lowest dose necessary to produce the desired effect should always be used (see section 4.2). ... Because a severe toxic reaction to phenylephrine is of rapid onset and short duration, treatment is primarily supportive. Prompt injection of a rapidly acting alpha-adrenergic blocking agent such as phentolamine (dose 2 to 5mg iv) has been ... Web25. jan 2024 · Maximum dose: 60 mg in 24 hours 6 to 12 years: Immediate release: 30 mg orally every 4 to 6 hours as needed Maximum dose: 120 mg in 24 hours 12 years or older: Immediate release: 30 to 60 mg orally every 4 to 6 hours as needed 12-hour extended- release: 120 mg orally every 12 hours as needed toyota dealership royersford pa

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Web5.8 Renal Toxicity . Phenylephrine hydrochloride can increase the need for renal replacement therapy in patients with septic shock. ... data indicate decreased responsiveness to phenylephrine. Consider using larger doses than usual in hepatic impaired subjects. 8.7 Renal Impairment . In patients with end stage renal disease (ESRD) … WebNo adverse effects on fertility or early embryonic development were noted when phenylephrine hydrochloride was administered at doses of 50 mcg, 100 mcg, or 200 mcg/kg/day (up to 0.2 times HDD of 10 mg/60 kg/day based on body surface area) via single daily bolus injection for 28 days prior to mating to male rats or for 14 days prior to mating ... WebInitially 2–5 mg (max. per dose 5 mg), followed by 1–10 mg, after at least 15 minutes if required. By slow intravenous injection. Child 1–11 years. Initially 5–20 micrograms/kg … toyota dealership salem oregon